![]() ![]() However, Goldman and co-workers subsequently demonstrated that a loss-of-function mutation in the SLC46A gene is the molecular basis for hereditary folate malabsorption. It was proposed that enterocytes’ acquisition of heme requires the activity of the SLC46A1 (a.k.a., heme carrier protein 1) transporter. Heme uptake, while constituting a significant iron source for many mammals, is poorly understood. As for the uptake of inorganic iron, these polarized cells express both DMT1 and the cytochrome b ferrireductase, Dcytb, on their apical membrane (the functions of DMT1 and Dcytb are defined later). Dietary iron enters the body primarily through duodenal enterocytes. ![]() 1A) in addition to a more recent adaptation of the former ( Fig. For historical interest, we have included an original version of the cycle, as determined by early ferrokinetic studies by Pollycove and Mortimer in 1961 ( Fig. Overview of Mammalian Iron Metabolismįigure 1 illustrates the iron cycle in humans and provides the approximate size of each iron pool. ![]()
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